The best weight-loss injections in 2025

Jump to: Comparison at a glance | 1. Tirzepatide (Mounjaro) | 2. Semaglutide (Wegovy) | 3. Liraglutide (Saxenda) | NHS vs private access | Side effects comparison | Cost analysis | How to choose | Future medications | Frequently asked questions | Take home message

Based on data from randomised controlled trials, the most effective weight-loss injection available in the UK in 2025 is tirzepatide (Mounjaro), which supports an average weight loss of 20-25% of starting body weight after 72 weeks¹.Weight-Loss Injections

While Mounjaro leads in effectiveness, choosing the right weight-loss injection depends on multiple factors, including your health conditions, budget, NHS eligibility, and how your body responds to different medications.

The three main weight-loss injections currently available in the UK are tirzepatide (Mounjaro), semaglutide (Wegovy), and liraglutide (Saxenda).

Most people in the UK access these medications through private prescriptions costing ~£150-400 a month, as NHS availability remains extremely limited despite NICE approval for certain medications.

Important safety information: Mounjaro (tirzepatide), Wegovy (semaglutide), and Saxenda (liraglutide) are prescription-only medications for treating type 2 diabetes and managing obesity. Always consult with your healthcare provider before starting any new medication, particularly if you have had your gallbladder removed or have other health conditions.

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